ExplanationIntermediate
What is the role of pyruvate kinase in glycolysis according to the chapter?
Pyruvate kinase plays a crucial role in glycolysis by catalyzing the conversion of phosphoenolpyruvate to pyruvate, which is the final step of the glycolytic pathway. This reaction generates ATP through substrate-level phosphorylation, contributing to the net yield of ATP from glycolysis.
Key points
- Pyruvate kinase catalyzes the conversion of phosphoenolpyruvate to pyruvate.
- This reaction is the final step in glycolysis.
- It generates ATP via substrate-level phosphorylation.
- Pyruvate is the end product of glycolysis.
Source:Marks' Basic Medical Biochemistry: A Clinical Approach· Generation of Adenosine Triphosphate from Glucose, Fructose, and Galactose: Glycolysis· p. 448–452
Marks' Basic Medical Biochemistry: A Clinical Approach
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5TH EDITION · Wolters Kluwer