SignificanceIntermediate
What limitations do peptide drugs have in clinical practice according to the chapter?
Peptide drugs have limitations in clinical practice primarily because they cannot be administered orally due to degradation in the gut and poor absorption. Additionally, they typically have short half-lives because peptide enzyme systems are well established in blood and tissues.
Key points
- Peptide drugs cannot be given orally due to gut degradation.
- They have poor absorption when taken orally.
- Peptides generally have short half-lives in the body.
- Peptide enzyme systems in blood and tissues rapidly break down peptides.
Source:Fundamentals of Pharmacology: An Applied Approach for Nursing and Health· Introduction to chemical mediators· p. 311–313
Fundamentals of Pharmacology: An Applied Approach for Nursing and Health
Alan Galbraith ... [et Al.].
Second Edition · Routledge