ExplanationIntermediate
What are the two mechanisms by which tramadol produces analgesia?
Tramadol produces analgesia through two mechanisms: it acts as a weak agonist at opioid receptors, particularly the μ receptor, and it inhibits the reuptake of noradrenaline while enhancing serotonin release in central pain pathways.
Key points
- Tramadol is a synthetic opioid used for moderate to severe pain.
- It has weak agonist activity at opioid receptors, especially μ receptors.
- Tramadol inhibits noradrenaline reuptake and enhances serotonin release.
- These mechanisms contribute to its analgesic effects.
Source:Fundamentals of Pharmacology: An Applied Approach for Nursing and Health· Non-steroidal anti-inflammatory, antipyretic and analgesic drugs· p. 419–423
Fundamentals of Pharmacology: An Applied Approach for Nursing and Health
Alan Galbraith ... [et Al.].
Second Edition · Routledge