What role do tumor-suppressor genes play in the development of cancer according to the chapter?

Tumor-suppressor genes play a crucial role in controlling cell division and maintaining genetic stability. They inhibit cell division and can trigger programmed cell death if DNA damage is detected. Mutations in these genes can lead to uncontrolled cell division, contributing to cancer development.

Tumor-suppressor genes are essential components of the cell's damage control system. They help detect damaged DNA and coordinate repair processes. If the damage is too severe, these genes can initiate cell death to prevent the propagation of damaged cells. When tumor-suppressor genes, such as p53, are mutated, their ability to regulate cell division and trigger apoptosis is compromised, allowing cells to divide uncontrollably and potentially lead to cancer.